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Pfizer's Sutent enjoys this position now -- but might have to share it with Cabometyx before too long. In a mid-stage clinical trial, Cabometyx reduced patients' risk of disease progression or death by 31% compared with the standard therapy. The case for Novartis Unlike Exelixis, the Swiss pharma giant has dozens of products pushing and pulling at its top line. Unfortunately, sales of its former top-selling product, the blood cancer drug Gleevec, are contracting due to generic competition. As a result, the company's top line has been sliding, and so has its stock price over the past 18 months. Luckily, a handful of recent launches are positioned to help offset those losses. In particular, psoriasis treatment Cosentyx earned approval in 2015, and it finished the third quarter on an annualized run rate of $1.32 billion. The drug outperformed Johnson & Johnson's popular Stelara in a clinical trial, and could generate annual sales of around $4 billion at its peak. Heart failure drug Entresto could be Novartis' largest growth driver, but its launch has been somewhat disappointing. In a clinical outcome study, it reduced patient risk of heart failure hospitalizations and cardiovascular death by at least 20% compared with the standard ACE inhibitor, enalapril.With millions of heart failure patients eligible for treatment, peak annual sales estimates top out at around $10 billion. Unfortunately, end payers haven't been too thrilled about replacing cheap, generic ACE inhibitors with Entresto, which costs around $4,600 per year.However, more than a year following its launch, U.S.


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